Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius
To investigate how hyperthermophilic archaea can propagate their genomes accurately, we isolated Sulfolobus acidocaldarius mutants exhibiting abnormally high rates of spontaneous mutation. Our isolation strategy involved enrichment for mutator lineages via alternating selections, followed by screeni...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2002-01-01
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| Series: | Archaea |
| Online Access: | http://dx.doi.org/10.1155/2002/516074 |