Nobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates G1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of JEG-3 and BeWo via regulating the p53 signaling pathway

Nobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates G1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of JEG-3 and BeWo via regulating the p53 signaling pathway

Background: Hypoxia is associated with abnormal cell apoptosis in trophoblast cells, which causes fetal growth restriction and related placental pathologies. Few effective methods for the prevention and treatment of placenta-related diseases exist. Natural products and functional foods have always b...

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Bibliographic Details
Main Authors: Mengling Zhang, Jian Liu, Rui Zhang, Zengenni Liang, Shenghua Ding, Huanling Yu, Yang Shan
Format: Article
Language:English
Published: Swedish Nutrition Foundation 2020-09-01
Series:Food & Nutrition Research
Subjects:
nobiletin
p53
molecular docking
molecular dynamics
spectrum
apoptosis
trophoblast cells
Online Access:https://foodandnutritionresearch.net/index.php/fnr/article/view/5649/13909

Internet

https://foodandnutritionresearch.net/index.php/fnr/article/view/5649/13909

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