Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

The PP2A phosphatase is often inactivated in cancer and is considered as a tumour suppressor. A new pathway controlling PP2A activity in mitosis has been recently described. This pathway includes the Greatwall (GWL) kinase and its substrates endosulfines. At mitotic entry, GWL is activated and phosp...

Full description

Bibliographic Details
Main Authors: Jorge Vera, Lydia Lartigue, Suzanne Vigneron, Gilles Gadea, Veronique Gire, Maguy Del Rio, Isabelle Soubeyran, Frederic Chibon, Thierry Lorca, Anna Castro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
Greatwall
Akt
PHLPP
oncogene
PP2A
cell invasion
Online Access:https://elifesciences.org/articles/10115

Internet

https://elifesciences.org/articles/10115

Similar Items