Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice

Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons (MN). Importantly, MN degeneration is intimately linked to oligodendrocyte dysfunction and impaired capacity of oligodendrocyte precursor cells (OPCs) to regenerate the myelin sheath...

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Bibliographic Details
Main Authors: Elisabetta Bonfanti, Tiziana Bonifacino, Stefano Raffaele, Marco Milanese, Erica Morgante, Giambattista Bonanno, Maria P. Abbracchio, Marta Fumagalli
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
G protein-coupled receptor 17 (GPR17)
amyotrophic lateral sclerosis (ALS)
SOD1<sup>G93A</sup> ALS mouse model
oligodendrocytes
montelukast
Online Access:https://www.mdpi.com/1422-0067/21/7/2395

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https://www.mdpi.com/1422-0067/21/7/2395

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