Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report

Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report

Abstract Background Aggressive squamous cell carcinomas (SCCs) present frequently in the context of chronic skin injury occurring in patients with the congenital blistering disease recessive dystrophic epidermolysis bullosa. Recently, these cancers were shown to harbor mutation signatures associated...

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Bibliographic Details
Main Authors: Jena Patel, Nicoline Y. den Breems, Madalina Tuluc, Jennifer Johnson, Joseph M Curry, Andrew P. South, Raymond J. Cho
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Medical Case Reports
Subjects:
APOBEC
Squamous cell carcinoma
RDEB
Epithelial injury
Online Access:https://doi.org/10.1186/s13256-021-02685-w

Internet

https://doi.org/10.1186/s13256-021-02685-w

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