Prevalence and Incidence of Non-neutralizing Antibodies in Congenital Hemophilia A— A Systematic Review and Meta-Analysis

Prevalence and Incidence of Non-neutralizing Antibodies in Congenital Hemophilia A— A Systematic Review and Meta-Analysis

Objectives: In hemophilia A the presence of non-neutralizing antibodies (NNAs) against Factor VIII (FVIII) may predict the development of neutralizing antibodies (inhibitors) and accelerate the clearance of administrated FVIII concentrates. This systematic review aimed to assess: (1) the prevalence...

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Bibliographic Details
Main Authors: A. Abdi, M. R. Bordbar, S. Hassan, F. R. Rosendaal, J. G. van der Bom, J. Voorberg, K. Fijnvandraat, S. C. Gouw
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
hemophilia
FVIII
FIX
non-neutralizing antibodies
anti-drug antibodies
ADA assay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00563/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00563/full

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