Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.

Bibliographic Details
Main Authors: Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10023-4

Internet

https://doi.org/10.1038/s41467-019-10023-4

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