Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS.

Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS.

Systemic exposure to the inflammagen and bacterial endotoxin lipopolysaccharide (LPS) has been widely used to evaluate inflammation and sickness behavior. While many inflammatory conditions occur in the periphery, it is well established that peripheral inflammation can affect the brain. Neuroinflamm...

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Bibliographic Details
Main Authors: Kimberly A Kelly, Lindsay T Michalovicz, Julie V Miller, Vincent Castranova, Diane B Miller, James P O'Callaghan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0190546

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https://doi.org/10.1371/journal.pone.0190546

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