Changes in Apoptotic Pathways in MOLM-13 Cell Lines after Induction of Resistance to Hypomethylating Agents

Changes in Apoptotic Pathways in MOLM-13 Cell Lines after Induction of Resistance to Hypomethylating Agents

We established the following two variants of the MOLM-13 human acute myeloid leukemia (AML) cell line: (i) MOLM-13/DAC cells are resistant to 5-aza-2′-deoxycytidine (DAC), and (ii) MOLM-13/AZA are resistant to 5-azacytidine (AZA). Both cell variants were obtained through a six-month selection/adapta...

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Bibliographic Details
Main Authors: Ľuboš Janotka, Lucia Messingerová, Kristína Šimoničová, Helena Kavcová, Katarína Elefantová, Zdena Sulová, Albert Breier
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
AML cell drug resistance
5-aza-2′-deoxycytidine
5-azacytidine
intrinsic and extrinsic pathways of apoptosis
promoter methylation
NF-κB pathway
Online Access:https://www.mdpi.com/1422-0067/22/4/2076

Internet

https://www.mdpi.com/1422-0067/22/4/2076

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