HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice

HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice

Abstract Background Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic vaccines have been developed for two decades, but none have yielded prom...

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Bibliographic Details
Main Authors: Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding-Shinn Chen, Pei-Jer Chen
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biomedical Science
Subjects:
Chronic hepatitis B
Immunotherapy
Hepatic innate immunity
Myeloid cell
Online Access:http://link.springer.com/article/10.1186/s12929-020-00662-x

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http://link.springer.com/article/10.1186/s12929-020-00662-x

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