Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

Anti-PD1/PDL1 therapy has proven efficacious against many cancers but only reached modest objective response rates against recurrent ovarian cancer. A deeper understanding of the tumor microenvironment (TME) may reveal other immunosuppressive mechanisms that warrant investigation as immunotherapeuti...

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Bibliographic Details
Main Authors: Marie Christine Wulff Westergaard, Katy Milne, Magnus Pedersen, Thomas Hasselager, Lars Rønn Olsen, Michael S. Anglesio, Troels Holz Borch, Mia Kennedy, Gillian Briggs, Stacey Ledoux, Caroline Kreuzinger, Isabel von der Decken, Marco Donia, Dan Cacsire Castillo-Tong, Brad H. Nelson, Inge Marie Svane
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
ovarian cancer
tumor microenvironment
immune checkpoints
TILs
multicolor immunohistochemistry (IHC)
NanoString
Online Access:https://www.mdpi.com/2072-6694/12/12/3828

Internet

https://www.mdpi.com/2072-6694/12/12/3828

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