Physiology and Pathophysiology of CLC-1: Mechanisms of a Chloride Channel Disease, Myotonia

The CLC-1 chloride channel, a member of the CLC-channel/transporter family, plays important roles for the physiological functions of skeletal muscles. The opening of this chloride channel is voltage dependent and is also regulated by protons and chloride ions. Mutations of the gene encoding CLC-1 re...

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Bibliographic Details
Main Authors: Chih-Yung Tang, Tsung-Yu Chen
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/685328