Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives

Summary: Background: Apolipoprotein B (apoB) is emerging as the crucial lipoprotein trait for the role of lipoprotein lipids in the aetiology of coronary heart disease. In this study, we evaluated the effects of genetically predicted apoB on outcomes in first-degree relatives. Methods: Data on lipo...

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Main Authors: Tom G Richardson, PhD, Qin Wang, PhD, Eleanor Sanderson, PhD, Anubha Mahajan, PhD, Mark I McCarthy, ProfMD, Timothy M Frayling, ProfPhD, Mika Ala-Korpela, ProfPhD, Allan Sniderman, ProfMD, George Davey Smith, ProfFRS, Michael V Holmes, MD
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:The Lancet. Healthy Longevity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666756821000866

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http://www.sciencedirect.com/science/article/pii/S2666756821000866

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