Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.

Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.

Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents (VNAs) consisting of two or more linked, toxin-neutralizing heavy-chain-only VH domains (VHHs), each binding distinct epitopes, can potently...

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Bibliographic Details
Main Authors: Jean Mukherjee, Igor Dmitriev, Michelle Debatis, Jacqueline M Tremblay, Gillian Beamer, Elena A Kashentseva, David T Curiel, Charles B Shoemaker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4149568?pdf=render

Internet

http://europepmc.org/articles/PMC4149568?pdf=render

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