The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury

The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury

Abstract Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms underlying microglial function in neuropathic pain are not fully understood. We identified that the voltage-gated proton channel Hv1, whi...

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Bibliographic Details
Main Authors: Jiyun Peng, Min-Hee Yi, Heejin Jeong, Przemyslaw Peter McEwan, Jiaying Zheng, Gongxiong Wu, Shashank Ganatra, Yi Ren, Jason R. Richardson, Seog Bae Oh, Long-Jun Wu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Brain
Subjects:
Microglia
Hv1 proton channel
Hvcn1
Reactive oxygen species
IFN-γ
Microglia-astrocyte interaction
Online Access:https://doi.org/10.1186/s13041-021-00812-8

Internet

https://doi.org/10.1186/s13041-021-00812-8

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