A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

In vitro pharmacokinetic studies were conducted on enantiomer pairs of twelve valinate or <i>tert</i>-leucinate indole and indazole-3-carboxamide synthetic cannabinoid receptor agonists (SCRAs) detected on the illicit drug market to investigate their physicochemical parameters and struct...

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Bibliographic Details
Main Authors: Andrew M. Brandon, Lysbeth H. Antonides, Jennifer Riley, Ola Epemolu, Denise A. McKeown, Kevin D. Read, Craig McKenzie
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
new psychoactive substances
synthetic cannabinoid receptor agonists
in vitro metabolism
in vivo prediction
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/26/5/1396

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https://www.mdpi.com/1420-3049/26/5/1396

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