Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia

Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia

Background: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphi...

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Bibliographic Details
Main Authors: Marília Rocha Laurentino, Pedro Aurio Maia Filho, Maritza Cavalcante Barbosa, Izabel Cristina Justino Bandeira, Lilianne Brito da Silva Rocha, Romelia Pinheiro Gonçalves
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Anemia, sickle cell
Inflammation
Tumor necrosis factor-alpha
Haplotypes
Hydroxyurea
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000200121&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000200121&lng=en&tlng=en

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