Dapagliflozin Regulates Cardiac Metabolic Remodeling Partially via Uncoupling Protein 3 in a Nondiabetic Thoracic Aortic Constriction-Induced Mouse Model

Dapagliflozin Regulates Cardiac Metabolic Remodeling Partially via Uncoupling Protein 3 in a Nondiabetic Thoracic Aortic Constriction-Induced Mouse Model

Objectives: We aimed to examine the protective effects of dapagliflozin (dapa) on thoracic aortic constriction (TAC)-induced heart failure in a nondiabetic mouse model. More specifically, we determined the effects of dapa on uncoupling protein 3 (UCP3) activation and subsequent metabolic remodeling....

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Bibliographic Details
Main Authors: Li-Wen Bao, Rong-Chen Liu, Fang-Ying Yan, Hui-Hua Fan, Guo-Qian Huang, Xiu-Fang Gao, Kun Xie, Yong Li, Hai-Ming Shi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Cardiology Plus
Subjects:
dapagliflozin; fatty acids; metabolic remodeling; uncoupling protein 3
Online Access:http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2021;volume=6;issue=2;spage=109;epage=120;aulast=Bao

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http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2021;volume=6;issue=2;spage=109;epage=120;aulast=Bao

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