Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs. Host Disease

Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs. Host Disease

The success of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of hematological malignancies remains hampered by life-threatening chronic graft vs. host disease (cGVHD). Although multifactorial in nature, cGVHD has been associated with imbalances between effector and...

Full description

Bibliographic Details
Main Authors: Maria V. Soares, Rita I. Azevedo, Inês A. Ferreira, Sara Bucar, Ana C. Ribeiro, Ana Vieira, Paulo N. G. Pereira, Ruy M. Ribeiro, Dario Ligeiro, Ana C. Alho, António S. Soares, Nádia Camacho, Carlos Martins, Fernanda Lourenço, Raul Moreno, Jerome Ritz, João F. Lacerda
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
chronic graft vs. host disease
hematopoietic stem cell transplantation
T lymphocyte
stem cell memory
Naive T cell
immune reconstitution
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00334/full

Similar Items