Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion

Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion

Altered macrophage infiltration upon tissue damage results in inadequate healing due to inappropriate remodeling and stem cell recruitment and differentiation. We investigated in vivo whether cells of endothelial origin phenotypically change upon heterotopic ossification induction and whether infilt...

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Bibliographic Details
Main Authors: Mario Tirone, Anna Giovenzana, Arianna Vallone, Paola Zordan, Martina Sormani, Pier Andrea Nicolosi, Raffaela Meneveri, Carmen Rosaria Gigliotti, Antonello E. Spinelli, Renata Bocciardi, Roberto Ravazzolo, Ingrid Cifola, Silvia Brunelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
macrophage
endothelial cell (EC)
heterotopic ossification (HO)
EndoMT
endothelial progenitors cells
RNASeq and NGS data analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01640/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01640/full

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