Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells

Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells

Abstract Flavopiridol (FP) is a pan-cyclin dependent kinase inhibitor, which shows strong efficacy in inducing cancer cell apoptosis. Although FP is potent against most cancer cells in vitro, unfortunately it proved less efficacious in clinical trials in various aggressive cancers. To date, the mole...

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Bibliographic Details
Main Authors: Xiaoran Li, Jie Lu, Quancheng Kan, Xiaoli Li, Qiong Fan, Yaqing Li, Ruixia Huang, Ana Slipicevic, Hiep Phuc Dong, Lars Eide, Junbai Wang, Hongquan Zhang, Viktor Berge, Mariusz Adam Goscinski, Gunnar Kvalheim, Jahn M. Nesland, Zhenhe Suo
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05086-6

Internet

https://doi.org/10.1038/s41598-017-05086-6

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