Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases
Cancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe side effects a...
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doaj-bc8f45f74a1b4bb791200e3ee84f50522020-11-25T00:10:45ZengMDPI AGCancers2072-66942018-05-0110514110.3390/cancers10050141cancers10050141Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal MetastasesSun H. Park0Matthew R. Eber1D. Brooke Widner2Yusuke Shiozawa3Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USACancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments for CIBP are desperately needed. Although the exact mechanisms of CIBP have not been fully elucidated, recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (e.g., osteoclasts, osteoblasts, macrophages, mast cells, mesenchymal stem cells, and fibroblasts) in CIBP development. Several clinical trials have been performed based on these findings. CIBP is a complex and challenging condition that currently has no standard effective treatments other than opioids. Further studies are clearly warranted to better understand this painful condition and develop more effective and safer targeted therapies.http://www.mdpi.com/2072-6694/10/5/141cancer-induced bone painbone marrow microenvironmentosteoclastsosteoblastsmacrophagesmast cellsstromal cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sun H. Park Matthew R. Eber D. Brooke Widner Yusuke Shiozawa |
spellingShingle |
Sun H. Park Matthew R. Eber D. Brooke Widner Yusuke Shiozawa Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases Cancers cancer-induced bone pain bone marrow microenvironment osteoclasts osteoblasts macrophages mast cells stromal cells |
author_facet |
Sun H. Park Matthew R. Eber D. Brooke Widner Yusuke Shiozawa |
author_sort |
Sun H. Park |
title |
Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases |
title_short |
Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases |
title_full |
Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases |
title_fullStr |
Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases |
title_full_unstemmed |
Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases |
title_sort |
role of the bone microenvironment in the development of painful complications of skeletal metastases |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2018-05-01 |
description |
Cancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments for CIBP are desperately needed. Although the exact mechanisms of CIBP have not been fully elucidated, recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (e.g., osteoclasts, osteoblasts, macrophages, mast cells, mesenchymal stem cells, and fibroblasts) in CIBP development. Several clinical trials have been performed based on these findings. CIBP is a complex and challenging condition that currently has no standard effective treatments other than opioids. Further studies are clearly warranted to better understand this painful condition and develop more effective and safer targeted therapies. |
topic |
cancer-induced bone pain bone marrow microenvironment osteoclasts osteoblasts macrophages mast cells stromal cells |
url |
http://www.mdpi.com/2072-6694/10/5/141 |
work_keys_str_mv |
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