Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation

Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation

Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a criti...

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Bibliographic Details
Main Authors: Otto Luiz Dutra Cerqueira, Maria Alejandra Clavijo-Salomon, Elaine Cristina Cardoso, Tharcisio Citrangulo Tortelli Junior, Samir Andrade Mendonça, José Alexandre M. Barbuto, Bryan E. Strauss
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
melanoma
adenovirus (Ad) vector
oncolysis
immunogenic cell death (ICD)
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.576658/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.576658/full

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