Pharmacological Agents Targeting the Cellular Prion Protein

Pharmacological Agents Targeting the Cellular Prion Protein

Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain tissues of affected individuals. PrPSc is a self-c...

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Bibliographic Details
Main Authors: Maria Letizia Barreca, Nunzio Iraci, Silvia Biggi, Violetta Cecchetti, Emiliano Biasini
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Pathogens
Subjects:
cellular prion protein
prion diseases
PrP ligands
pharmacological chaperones
Online Access:http://www.mdpi.com/2076-0817/7/1/27

Internet

http://www.mdpi.com/2076-0817/7/1/27

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