Effects of a postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice

Effects of a postnatal Atrx conditional knockout in neurons on autism-like behaviours in male and female mice

Abstract Background Alpha-thalassemia/mental retardation, X-linked, or ATRX, is an autism susceptibility gene that encodes a chromatin remodeler. Mutations of ATRX result in the ATR-X intellectual disability syndrome and have been identified in autism spectrum disorder (ASD) patients. The mechanisms...

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Bibliographic Details
Main Authors: Nicole Martin-Kenny, Nathalie G. Bérubé
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Autism spectrum disorder
ATRX
Social behaviours
Repetitive behaviours
Startle response
Genetically engineered mice
Online Access:http://link.springer.com/article/10.1186/s11689-020-09319-0

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http://link.springer.com/article/10.1186/s11689-020-09319-0

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