Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study

Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study

Distinct regulatory signaling mechanisms exist between cortisol and brain derived neurotrophic factor (BDNF) that may influence secondary injury cascades associated with traumatic brain injury (TBI) and predict outcome. We investigated concurrent CSF BDNF and cortisol relationships in 117 patients s...

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Bibliographic Details
Main Authors: Miranda J. Munoz, Raj G. Kumar, Byung-Mo Oh, Yvette P. Conley, Zhensheng Wang, Michelle D. Failla, Amy K. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cortisol
BDNF
TBI
biomarkers
genetics
cerebrospinal fluid
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00044/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00044/full

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