The effects of the Histone Deacetylase (HDAC) Inhibitor 4-Phenylbutyrate on gap junction conductance and permeability

Longitudinal resistance is a key factor in determining cardiac action potential propagation. Action potential conduction velocity has been shown to be proportional to the square root of longitudinal resistance. A major determinant of longitudinal resistance in myocardium is the gap junction channel,...

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Bibliographic Details
Main Authors: Joshua eKaufman, Chris eGordon, Roberto eBergamaschi, Hong Zhan Wang, Ira S Cohen, Virginijus eValiunas, Peter eBrink
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00111/full