Metronidazole thermogel improves retention and decreases permeation through the skin

Metronidazole thermogel improves retention and decreases permeation through the skin

ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are str...

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Bibliographic Details
Main Authors: Elayne Karine Souto de Melo, Thalita Pedon de Araujo, José Wellithom Viturino da Silva, Stephanye Carolyne Christino Chagas, Danilo César Galindo Bedor, Davi Pereira de Santana, Leila Bastos Leal
Format: Article
Language:English
Published: Universidade de São Paulo 2017-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Metronidazole/evaluation
Metronidazole/drug retention
Poloxamer 407
Rosacea/treatment
Dermatopharmacokinetic.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626&lng=en&tlng=en

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