Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models

Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models

Glioblastoma (GBM) is an aggressive malignancy with poor prognosis. New therapeutic strategies for GBM are urgently needed. Although clinical studies have demonstrated the feasibility and safety of chimeric antigen receptor (CAR) T cell therapy for GBM, its efficacy has not been that impressive. The...

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Bibliographic Details
Main Authors: You Li, Huifang Wu, Gang Chen, Xiaofan Wei, Chunyu Wang, Shanshan Zhou, Ailing Huang, Zui Zhang, Changyou Zhan, Yanling Wu, Tianlei Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
TGFβ
CAR-T
EGFRvIII
TGFRII
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01117/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01117/full

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