The Impact of Polymer Size and Cleavability on the Intravenous Pharmacokinetics of PEG-Based Hyperbranched Polymers in Rats

The Impact of Polymer Size and Cleavability on the Intravenous Pharmacokinetics of PEG-Based Hyperbranched Polymers in Rats

A better understanding of the impact of molecular size and linkers is important for PEG-based hyperbranched polymers (HBPs) intended as tailored drug delivery vehicles. This study aimed to evaluate the effects of crosslinker chemistry (cleavable disulphide versus non-cleavable ethylene glycol methac...

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Bibliographic Details
Main Authors: Nirmal Marasini, Changkui Fu, Nicholas L. Fletcher, Christopher Subasic, Gerald Er, Karine Mardon, Kristofer J. Thurecht, Andrew K. Whittaker, Lisa M. Kaminskas
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Nanomaterials
Subjects:
hyperbranched polymer
nanoparticles
nanomaterials
poly (ethylene glycol)
pharmacokinetics
biodistribution
Online Access:https://www.mdpi.com/2079-4991/10/12/2452

Internet

https://www.mdpi.com/2079-4991/10/12/2452

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