Blockage of the Epithelial-to-Mesenchymal Transition Is Required for Embryonic Stem Cell Derivation

Blockage of the Epithelial-to-Mesenchymal Transition Is Required for Embryonic Stem Cell Derivation

Pluripotent cells emanate from the inner cell mass (ICM) of the blastocyst and when cultivated under optimal conditions immortalize as embryonic stem cells (ESCs). The fundamental mechanism underlying ESC derivation has, however, remained elusive. Recently, we have devised a highly efficient approac...

Full description

Bibliographic Details
Main Authors: Mehdi Totonchi, Seyedeh-Nafiseh Hassani, Ali Sharifi-Zarchi, Natalia Tapia, Kenjiro Adachi, Julia Arand, Boris Greber, Davood Sabour, Marcos J. Araúzo-Bravo, Jörn Walter, Mohammad Pakzad, Hamid Gourabi, Hans R. Schöler, Hossein Baharvand
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
mouse
ESC derivation
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303636

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117303636

Similar Items