The endocannabinoid system is affected by cholesterol dyshomeostasis: Insights from a murine model of Niemann Pick type C disease

The endocannabinoid system is affected by cholesterol dyshomeostasis: Insights from a murine model of Niemann Pick type C disease

The dyshomeostasis of intracellular cholesterol trafficking is typical of the Niemann-Pick type C (NPC) disease, a fatal inherited lysosomal storage disorder presenting with progressive neurodegeneration and visceral organ involvement. In light of the well-established relevance of cholesterol in reg...

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Bibliographic Details
Main Authors: Sergio Oddi, Paola Caporali, Jessica Dragotto, Antonio Totaro, Marzia Maiolati, Lucia Scipioni, Clotilde Beatrice Angelucci, Cristina Orsini, Sonia Canterini, Cinzia Rapino, Mauro Maccarrone, Maria Teresa Fiorenza
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Lysosomal storage disorders
Genetic mouse models
Endocannabinoid system biochemistry
Behavioral phenotyping
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301998

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http://www.sciencedirect.com/science/article/pii/S0969996119301998

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