Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization

Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization

Two new thermophilic branched chain amino acid transaminases have been identified within the genomes of different hyper-thermophilic archaea, Geoglobus acetivorans, and Archaeoglobus fulgidus. These enzymes belong to the class IV of transaminases as defined by their structural fold. The enzymes have...

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Bibliographic Details
Main Authors: Michail N. Isupov, Konstantin M. Boyko, Jan-Moritz Sutter, Paul James, Christopher Sayer, Marcel Schmidt, Peter Schönheit, Alena Yu. Nikolaeva, Tatiana N. Stekhanova, Andrey V. Mardanov, Nikolai V. Ravin, Ekaterina Yu. Bezsudnova, Vladimir O. Popov, Jennifer A. Littlechild
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
thermophilic archaea
branched-chain aminotransferases
substrate specificity
X-ray structural analysis
biocatalysis
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00007/full

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00007/full

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