WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.

WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.

IL-27 is an important and non-redundant regulator of effector T cell accumulation in non-lymphoid tissues during infection. Using malaria as a model systemic pro-inflammatory infection, we demonstrate that the aberrant accumulation of CD4⁺ T cells in the liver of infected IL27R(-/-) (WSX-1(-/-)) mic...

Full description

Bibliographic Details
Main Authors: Ana Villegas-Mendez, Emily Gwyer Findlay, J Brian de Souza, Lisa-Marie Grady, Christiaan J Saris, Thomas E Lane, Eleanor M Riley, Kevin N Couper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3820588?pdf=render

Internet

http://europepmc.org/articles/PMC3820588?pdf=render

Similar Items