Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

Our goal was to examine the anticancer effects of piperine against the resistant human ovarian cancer cells and to explore the molecular mechanisms responsible for its anticancer effects. Our study used drug-sensitive ovarian cancer cell line W1 and its sublines resistant to paclitaxel (PAC) and top...

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Bibliographic Details
Main Authors: Karolina Wojtowicz, Karolina Sterzyńska, Monika Świerczewska, Michał Nowicki, Maciej Zabel, Radosław Januchowski
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
ovarian cancer
piperine
drug resistance
protein phosphorylation
drug transporters
cancer stem cells
Online Access:https://www.mdpi.com/1422-0067/22/8/4243

Internet

https://www.mdpi.com/1422-0067/22/8/4243

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