A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain

A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain

Abstract Background Acute promyelocytic leukemia (APL) is characterized by fusion of PML/RARα genes as a result of t(15;17)(q24;q21). APL is now one of the curable hematological malignancies thanks to molecularly targeted therapies based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATX)....

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Bibliographic Details
Main Authors: Filomena Nozza, Gabriella Vona, Stefania Trino, Fiorella D’Auria, Francesco La Rocca, Vitina Grieco, Luciana Possidente, Luciana De Luca, Pellegrino Musto
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Molecular Cytogenetics
Subjects:
Acute promyelocytic leukemia
Molecular cytogenetics
c-myc gene
FISH
Painting
Chromosome 8
Online Access:http://link.springer.com/article/10.1186/s13039-019-0445-1

Internet

http://link.springer.com/article/10.1186/s13039-019-0445-1

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