Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination.

Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination.

The Step trial raised the possibility that uncircumcised men with pre-existing Ad5 neutralizing antibodies carried an increased risk of HIV infection after vaccination. Thus, understanding Ad seropositivity in humans is important to the development of an AIDS vaccine. Here, we analyze the impact of...

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Bibliographic Details
Main Authors: Cheng Cheng, Lingshu Wang, Jason G D Gall, Martha Nason, Richard M Schwartz, M Juliana McElrath, Steven C DeRosa, John Hural, Lawrence Corey, Susan P Buchbinder, Gary J Nabel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3319553?pdf=render

Internet

http://europepmc.org/articles/PMC3319553?pdf=render

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