Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.

Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS) campaigns. Because up to several million different small molecules will be tested in a single HTS campaign, even small variability within the cell populations for screening could easily invalidate an entire camp...

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Bibliographic Details
Main Authors: Peter Reinhardt, Michael Glatza, Kathrin Hemmer, Yaroslav Tsytsyura, Cora S Thiel, Susanne Höing, Sören Moritz, Juan A Parga, Lydia Wagner, Jan M Bruder, Guangming Wu, Benjamin Schmid, Albrecht Röpke, Jürgen Klingauf, Jens C Schwamborn, Thomas Gasser, Hans R Schöler, Jared Sterneckert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3606479?pdf=render