New tirapazamine derivatives protect cardiomyocytes from doxorubicin toxicity

New tirapazamine derivatives protect cardiomyocytes from doxorubicin toxicity

Doxorubicin cardiotoxicity is caused by various mechanisms, most importantly by oxidative stress originating in the mitochondria. Tirapazamine is a hypoxia-activated anticancer experimental drug. Both drugs in normoxia conditions undergo univalent reduction, thus tirapazamine may compete with doxoru...

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Bibliographic Details
Main Authors: Korga Agnieszka, Iwan Magdalena, Matosiuk Dariusz, Rzadkowska Marzena, Szacon Elzbieta, Humeniuk Ewelina, Sysa Marcin, Ostrowska Marta, Dudka Jaroslaw
Format: Article
Language:English
Published: Sciendo 2020-03-01
Series:Current Issues in Pharmacy and Medical Sciences
Subjects:
doxorubicin
tirapazamine derivative
cardiotoxicity
triphenylphosphine cation
oxidative stress
Online Access:https://doi.org/10.2478/cipms-2020-0001

Internet

https://doi.org/10.2478/cipms-2020-0001

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