Suppression of mICAT in Mouse Small Intestinal Myocytes by General Anaesthetic Ketamine and its Recovery by TRPC4 Agonist (-)-englerin A

Suppression of mICAT in Mouse Small Intestinal Myocytes by General Anaesthetic Ketamine and its Recovery by TRPC4 Agonist (-)-englerin A

A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupli...

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Bibliographic Details
Main Authors: Mariia I. Melnyk, Dariia O. Dryn, Lina T. Al Kury, Dmytro O. Dziuba, Alexander V. Zholos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
ketamine
(-)-englerin A
gastrointestinal tract
G-proteins
postoperative ileus
transient receptor potential canonical subfamily member 4 channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.594882/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.594882/full

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