Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: Dissection of intracellular signalling pathways

Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: Dissection of intracellular signalling pathways

Clinical evidence suggest astrocytic abnormality in major depression while treatment with anti-psychotic drugs affects astroglial functions. Astroglial cells are involved in pH homeostasis of the brain by transporting protons (through sodium-proton transporter 1, NHE1, glutamate transporters EAAT1/2...

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Bibliographic Details
Main Authors: Jienan eRen, Dan eSong, Qiufang eBai, Alexej eVerkhratsky, Liang ePeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Astrocytes
Fluoxetine
Akt
NHE1
ERK1/2
pHi
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00061/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00061/full

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