Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell responses in acute HIV infection are predictive of disease pro...

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Bibliographic Details
Main Authors: Chansavath Phetsouphanh, Daniel Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete Van Vuuren, Dominique Goedhals, Sarah Fidler, Anthony Kelleher, Paul Klenerman, John Frater
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
T cells
HIV
viral immunology
CD4 T cells
cytotoxic T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01844/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01844/full

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