Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis

Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis

Background: Patients developing meningococcal septic shock reveal levels of Neisseria meningitidis (106-108/mL) and endotoxin (101-103 EU/mL) in the circulation and organs, leading to acute cardiovascular, pulmonary and renal failure, coagulopathy and a high case fatality rate within 24 h.Objective:...

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Bibliographic Details
Main Authors: Berit Sletbakk Brusletto, Else Marit Løberg, Bernt Christian Hellerud, Ingeborg Løstegaard Goverud, Jens Petter Berg, Ole Kristoffer Olstad, Unni Gopinathan, Petter Brandtzaeg, Reidun Øvstebø
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
FFPE
IHC
MOF
Neisseria meningitidis
septic shock
transcriptional profiles
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00042/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00042/full

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