KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization

Summary: Epigenomic changes and stem cell deterioration are two hallmarks of aging. Accumulating evidence suggest that senescence of mesenchymal stromal cells (MSCs) perpetuates aging or age-related diseases. Here we report that two H3K9 demethylases, KDM3A and KDM4C, regulate heterochromatin reorga...

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Bibliographic Details
Main Authors: Biao Huang, Bin Wang, Wayne Yuk-Wai Lee, Kin Pong U, Kam Tong Leung, Xican Li, Zhenqing Liu, Rui Chen, Jia cheng Lin, Lai Ling Tsang, Baohua Liu, Ye chun Ruan, Hsiao Chang Chan, Gang Li, Xiaohua Jiang
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219304213

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http://www.sciencedirect.com/science/article/pii/S2589004219304213

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