BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

Abstract Background Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation of the spinal dorsal horn (SDH) was associated with mechanisms of interstitial c...

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Bibliographic Details
Main Authors: Honglu Ding, Jialiang Chen, Minzhi Su, Zhijun Lin, Hailun Zhan, Fei Yang, Wenbiao Li, Juncong Xie, Yong Huang, Xianguo Liu, Bolong Liu, Xiangfu Zhou
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Cystitis
BDNF
TrkB
Neuroinflammation
Mechanical allodynia
Astrocytes
Online Access:https://doi.org/10.1186/s12974-020-1704-0

Internet

https://doi.org/10.1186/s12974-020-1704-0

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