Heterozygous mutation in IκBNS leads to reduced levels of natural IgM antibodies and impaired responses to T-independent type 2 antigens

Heterozygous mutation in IκBNS leads to reduced levels of natural IgM antibodies and impaired responses to T-independent type 2 antigens

Mice deficient in central components of classical NF-κB signaling have low levels of circulating natural IgM antibodies and fail to respond to immunization with T-independent type 2 (TI-2) antigens. A plausible explanation for these defects is the severely reduced numbers of B-1 and marginal zone B...

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Bibliographic Details
Main Authors: Gabriel Karlsson Pedersen, Monika eÁdori, julian M Stark, Sharesta eKhoenkhoen, Carrie eArnold, Bruce eBeutler, Gunilla B Karlsson Hedestam
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
B-1 cells
NF-κB
transitional B cells
Nfkbid
IκBNS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00065/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00065/full

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