Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation

Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation

The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investi...

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Bibliographic Details
Main Authors: Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov, Rudolf Zentel
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Polymers
Subjects:
cancer immune therapy
vaccination
dendritic cells (DCs)
pDNA polyplex
RAFT polymerization
targeting
DEC205 antibody
bioorthogonal chemistry
strain-promoted alkyne-azide cycloaddition (SPAAC)
Online Access:http://www.mdpi.com/2073-4360/10/2/141

Internet

http://www.mdpi.com/2073-4360/10/2/141

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