Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells

Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells

Mutations in gap junction beta-2 (GJB2), the gene that encodes connexin 26 (CX26), are the most frequent cause of hereditary deafness worldwide. We recently developed an in vitro model of GJB2-related deafness (induced CX26 gap junction-forming cells; iCX26GJCs) from mouse induced pluripotent stem c...

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Bibliographic Details
Main Authors: Ichiro Fukunaga, Yoko Oe, Cheng Chen, Keiko Danzaki, Sayaka Ohta, Akito Koike, Katsuhisa Ikeda, Kazusaku Kamiya
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
embryonic stem cells
SB431542
gap junction beta 2 gene
connexin 26 and 30
gap junction plaques
cochlear supporting cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.602197/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.602197/full

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