Gut Microbiome Homeostasis and the CD4 T- Follicular Helper Cell IgA Axis in Human Immunodeficiency Virus Infection

Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) are associated with severe perturbations in the gut mucosal environment characterized by massive viral replication and depletion of CD4 T cells leading to dysbiosis, breakdown of the epithelial barrier, microbial translocatio...

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Bibliographic Details
Main Authors: Olusegun O. Onabajo, Joseph J. Mattapallil
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
HIV
SIV
Tfh
IgA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.657679/full