Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection

Sulforaphane (SFN), an isothiocyanate naturally occurring in Cruciferae, induces cytoprotection in several tissues. Its protective effect has been associated with its ability to induce cytoprotective enzymes through an Nrf2-dependent pathway. Gentamicin (GM) is a widely used antibiotic; nephrotoxici...

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Bibliographic Details
Main Authors: Mario Negrette-Guzmán, Sara Huerta-Yepez, Omar Noel Medina-Campos, Zyanya Lucía Zatarain-Barrón, Rogelio Hernández-Pando, Ismael Torres, Edilia Tapia, José Pedraza-Chaverri
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2013/135314